| 14. Round | 06/02/2022 | Tottenham Hotspur WFC [Women] | - | Brighton & Hove Albion WFC [Women] | 4:0 |  |
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| 15. Round | 13/02/2022 | Birmingham City WFC [Women] | - | Tottenham Hotspur WFC [Women] | 0:2 | ||||
| 16. Round | 06/03/2022 | Reading WFC [Women] | - | Tottenham Hotspur WFC [Women] | 0:0 | |
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| 17. Round | 13/03/2022 | Tottenham Hotspur WFC [Women] | - | Manchester City WFC [Women] | 0:1 | ||||
| 19. Round | 03/04/2022 | Tottenham Hotspur WFC [Women] | - | Aston Villa WFC [Women] | 0:1 | ||||
| 20. Round | 24/04/2022 | Tottenham Hotspur WFC [Women] | - | Chelsea FC Women [Women] | 1:3 | ||||
| 11. Round | 28/04/2022 | Chelsea FC Women [Women] | - | Tottenham Hotspur WFC [Women] | 2:1 | ||||
| 21. Round | 01/05/2022 | Everton FC [Women] | - | Tottenham Hotspur WFC [Women] | 2:2 | ||||
| 18. Round | 04/05/2022 | Arsenal WFC [Women] | - | Tottenham Hotspur WFC [Women] | 3:0 | |
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| 22. Round | 08/05/2022 | Tottenham Hotspur WFC [Women] | - | Leicester City WFC [Women] | 1:0 |
Finland