| 11. Round | 14/09/2021 | Banfield II | - | Rosario Central II | 1:3 | ||||
| 12. Round | 17/09/2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 13. Round | 24/09/2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 14. Round | 01/10/2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 15. Round | 08/10/2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 16. Round | 13/10/2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 17. Round | 18/10/2021 | Platense II | - | Rosario Central II | 0:3 |  |
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| 18. Round | 24/10/2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 19. Round | 29/10/2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 22. Round | 24/11/2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 | ||||
| 23. Round | 28/11/2021 | Rosario Central II | - | River Plate II | 2:0 |  |
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| 24. Round | 03/12/2021 | Lanús II | - | Rosario Central II | 2:3 | ||||
| 25. Round | 10/12/2021 | Rosario Central II | - | Huracán II | 2:0 |
Argentina
Italy