31. Round | 08/02/2022 | Exeter City | - | Leyton Orient | 1:0 | ||||
32. Round | 12/02/2022 | Leyton Orient | - | Salford City | 0:2 | ||||
25. Round | 22/02/2022 | Leyton Orient | - | Bristol Rovers | 0:2 | ||||
34. Round | 26/02/2022 | Leyton Orient | - | Carlisle United | 0:1 | ||||
35. Round | 05/03/2022 | Leyton Orient | - | Stevenage FC | 2:2 | ||||
36. Round | 12/03/2022 | Hartlepool United | - | Leyton Orient | 0:0 | ||||
27. Round | 29/03/2022 | Oldham Athletic | - | Leyton Orient | 2:0 | ||||
40. Round | 02/04/2022 | Walsall FC | - | Leyton Orient | 0:2 |