| 2. Round | 04/09/1909 | Sunderland AFC | - | Preston North End | 2:1 | ||||
| 3. Round | 11/09/1909 | Preston North End | - | Everton FC | 0:1 | ||||
| 16. Round | 11/12/1909 | Preston North End | - | Woolwich Arsenal | 3:4 | ||||
| 17. Round | 18/12/1909 | Bolton Wanderers | - | Preston North End | 3:1 | ||||
| 27. Round | 26/02/1910 | Preston North End | - | Bury FC | 2:1 | ||||
| 28. Round | 05/03/1910 | Tottenham Hotspur | - | Preston North End | 2:1 |  |
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| 29. Round | 12/03/1910 | Middlesbrough FC | - | Preston North End | 1:0 | ||||
| 30. Round | 19/03/1910 | Preston North End | - | Notts County | 4:0 | ||||
| 31. Round | 25/03/1910 | Nottingham Forest | - | Preston North End | 0:0 | ||||
| 24. Round | 29/03/1910 | Bradford City | - | Preston North End | 2:0 | ||||
| 34. Round | 02/04/1910 | Preston North End | - | Liverpool FC | 2:0 | ||||
| 35. Round | 09/04/1910 | Aston Villa | - | Preston North End | 3:0 | ||||
| 36. Round | 16/04/1910 | Preston North End | - | Sheffield United | 1:1 | ||||
| 37. Round | 23/04/1910 | Woolwich Arsenal | - | Preston North End | 1:3 | ||||
| 38. Round | 30/04/1910 | Preston North End | - | Bolton Wanderers | 1:0 |
England