| 1. Round | 12/09/2020 | Plymouth Argyle | - | Blackpool FC | 1:0 | ||||
| 2. Round | 19/09/2020 | AFC Wimbledon | - | Plymouth Argyle | 4:4 |  |
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| 3. Round | 26/09/2020 | Plymouth Argyle | - | Shrewsbury Town | 1:1 | ||||
| 4. Round | 03/10/2020 | Hull City | - | Plymouth Argyle | 1:0 | ||||
| 5. Round | 10/10/2020 | Plymouth Argyle | - | Burton Albion | 2:0 | ||||
| 6. Round | 17/10/2020 | Plymouth Argyle | - | Northampton Town | 2:1 |  |
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| 7. Round | 20/10/2020 | Lincoln City | - | Plymouth Argyle | 2:0 | ||||
| 12. Round | 16/11/2020 | Plymouth Argyle | - | Portsmouth FC | 2:2 | ||||
| 14. Round | 24/11/2020 | Peterborough United | - | Plymouth Argyle | 1:0 | ||||
| 15. Round | 01/12/2020 | Plymouth Argyle | - | Rochdale AFC | 0:4 | ||||
| 17. Round | 12/12/2020 | Bristol Rovers | - | Plymouth Argyle | 3:0 | ||||
| 18. Round | 15/12/2020 | Crewe Alexandra | - | Plymouth Argyle | 2:1 |
England