| 1. Round | 14/08/2021 | Liverpool FC [U18] | - | Stoke City [U18] | 5:3 | ||||
| 5. Round | 25/09/2021 | Manchester United [U18] | - | Stoke City [U18] | 4:2 | ||||
| 7. Round | 23/10/2021 | Leeds United [U18] | - | Stoke City [U18] | 0:2 | ||||
| 8. Round | 30/10/2021 | Middlesbrough FC [U18] | - | Stoke City [U18] | 1:1 | ||||
| 9. Round | 05/11/2021 | Stoke City [U18] | - | Burnley FC [U18] | 1:3 | ||||
| 10. Round | 20/11/2021 | Derby County [U18] | - | Stoke City [U18] | 2:1 | ||||
| 11. Round | 04/12/2021 | Stoke City [U18] | - | Manchester City [U18] | 2:0 | ||||
| 12. Round | 18/12/2021 | Stoke City [U18] | - | Wolverhampton Wanderers [U18] | 0:4 |  |
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| 13. Round | 08/01/2022 | Everton FC [U18] | - | Stoke City [U18] | 2:2 |  |
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| 15. Round | 22/01/2022 | Manchester City [U18] | - | Stoke City [U18] | 5:0 | ||||
| 16. Round | 05/02/2022 | Stoke City [U18] | - | Middlesbrough FC [U18] | 1:2 |
England