1. Round 06/08/2011 Walsall FC - Leyton Orient 1:0
2. Round 13/08/2011 Leyton Orient - Tranmere Rovers 0:1
3. Round 16/08/2011 Leyton Orient - Wycombe Wanderers 1:3
6. Round 03/09/2011 Chesterfield FC - Leyton Orient 0:0
7. Round 10/09/2011 Colchester United - Leyton Orient 1:1
8. Round 13/09/2011 Leyton Orient - AFC Bournemouth 1:3
9. Round 17/09/2011 Leyton Orient - Oldham Athletic 1:3 Goal
10. Round 24/09/2011 Huddersfield Town - Leyton Orient 2:2
11. Round 01/10/2011 Leyton Orient - Preston North End 2:1
13. Round 15/10/2011 Leyton Orient - Bury FC 1:0
14. Round 22/10/2011 Leyton Orient - Sheffield United 1:1
15. Round 25/10/2011 Yeovil Town - Leyton Orient 2:2
16. Round 29/10/2011 Rochdale AFC - Leyton Orient 0:2
17. Round 05/11/2011 Leyton Orient - Hartlepool United 1:1
18. Round 19/11/2011 Leyton Orient - Stevenage FC 0:0
19. Round 26/11/2011 Sheffield Wednesday - Leyton Orient 1:0
20. Round 10/12/2011 Leyton Orient - Exeter City 3:0
21. Round 17/12/2011 Notts County - Leyton Orient 1:2
22. Round 26/12/2011 Leyton Orient - Milton Keynes Dons 0:3
24. Round 02/01/2012 Stevenage FC - Leyton Orient 0:1
28. Round 28/01/2012 Leyton Orient - Colchester United 0:1
31. Round 14/02/2012 AFC Bournemouth - Leyton Orient 1:2
32. Round 18/02/2012 Leyton Orient - Scunthorpe United 1:3
33. Round 25/02/2012 Bury FC - Leyton Orient 1:1
35. Round 06/03/2012 Wycombe Wanderers - Leyton Orient 4:2
36. Round 10/03/2012 Tranmere Rovers - Leyton Orient 2:0
39. Round 24/03/2012 Leyton Orient - Sheffield Wednesday 0:1
29. Round 27/03/2012 Oldham Athletic - Leyton Orient 0:1
40. Round 31/03/2012 Charlton Athletic - Leyton Orient 2:0
30. Round 03/04/2012 Leyton Orient - Huddersfield Town 1:3
41. Round 06/04/2012 Leyton Orient - Notts County 0:3
42. Round 09/04/2012 Exeter City - Leyton Orient 3:0
43. Round 14/04/2012 Sheffield United - Leyton Orient 3:1
45. Round 28/04/2012 Hartlepool United - Leyton Orient 2:1