| 13. Round | 16/10/2021 | Bolton Wanderers | - | Wigan Athletic | 0:4 |  |
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| 18. Round | 20/11/2021 | Wycombe Wanderers | - | Bolton Wanderers | 1:0 | ||||
| 19. Round | 23/11/2021 | Bolton Wanderers | - | Doncaster Rovers | 3:0 |  |
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| 20. Round | 27/11/2021 | Bolton Wanderers | - | Cheltenham Town | 2:2 | |
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| 21. Round | 07/12/2021 | Fleetwood Town | - | Bolton Wanderers | 3:0 | ||||
| 22. Round | 11/12/2021 | Accrington Stanley | - | Bolton Wanderers | 1:0 | ||||
| 26. Round | 01/01/2022 | Rotherham United | - | Bolton Wanderers | 2:1 | ||||
| 23. Round | 11/01/2022 | Bolton Wanderers | - | Wycombe Wanderers | 0:2 | ||||
| 27. Round | 01/02/2022 | Bolton Wanderers | - | Cambridge United | 2:0 | ||||
| 34. Round | 19/02/2022 | Bolton Wanderers | - | AFC Wimbledon | 4:0 | ||||
| 37. Round | 05/03/2022 | Gillingham FC | - | Bolton Wanderers | 0:3 | ||||
| 43. Round | 15/04/2022 | Doncaster Rovers | - | Bolton Wanderers | 1:2 | |
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| 46. Round | 30/04/2022 | Bolton Wanderers | - | Fleetwood Town | 4:2 |
England