| 25. Round | 01/01/2022 | Scunthorpe United | - | Carlisle United | 0:1 | ||||
| 27. Round | 15/01/2022 | Exeter City | - | Scunthorpe United | 2:0 | ||||
| 22. Round | 25/01/2022 | Scunthorpe United | - | Bristol Rovers | 2:3 | ||||
| 29. Round | 29/01/2022 | Port Vale FC | - | Scunthorpe United | 1:0 | ||||
| 30. Round | 05/02/2022 | Scunthorpe United | - | Oldham Athletic | 0:1 |  |
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| 37. Round | 15/03/2022 | Scunthorpe United | - | Barrow AFC | 0:1 | ||||
| 38. Round | 19/03/2022 | Salford City | - | Scunthorpe United | 5:1 | ||||
| 39. Round | 26/03/2022 | Scunthorpe United | - | Harrogate Town | 0:3 | ||||
| 40. Round | 02/04/2022 | Forest Green Rovers | - | Scunthorpe United | 1:0 | ||||
| 41. Round | 09/04/2022 | Scunthorpe United | - | Mansfield Town | 0:4 | ||||
| 43. Round | 18/04/2022 | Scunthorpe United | - | Stevenage FC | 1:1 |
England