| 1. Round | 07/08/2021 | Scunthorpe United | - | Swindon Town | 1:3 | ||||
| 2. Round | 14/08/2021 | Swindon Town | - | Carlisle United | 1:2 | ||||
| 3. Round | 17/08/2021 | Swindon Town | - | Tranmere Rovers | 0:0 | ||||
| 7. Round | 11/09/2021 | Swindon Town | - | Port Vale FC | 1:2 |  |
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| 26. Round | 11/01/2022 | Mansfield Town | - | Swindon Town | 3:2 | ||||
| 31. Round | 08/02/2022 | Tranmere Rovers | - | Swindon Town | 3:0 | ||||
| 33. Round | 19/02/2022 | Carlisle United | - | Swindon Town | 0:3 | ||||
| 22. Round | 22/02/2022 | Swindon Town | - | Walsall FC | 5:0 | ||||
| 34. Round | 26/02/2022 | Swindon Town | - | Salford City | 1:2 | ||||
| 36. Round | 12/03/2022 | Swindon Town | - | Oldham Athletic | 1:0 | ||||
| 38. Round | 19/03/2022 | Crawley Town | - | Swindon Town | 3:1 | ||||
| 40. Round | 02/04/2022 | Rochdale AFC | - | Swindon Town | 0:0 | ||||
| 42. Round | 15/04/2022 | Harrogate Town | - | Swindon Town | 1:4 | ||||
| 43. Round | 18/04/2022 | Swindon Town | - | Leyton Orient | 1:2 | ||||
| 44. Round | 23/04/2022 | Hartlepool United | - | Swindon Town | 0:3 |
England