| 29. Round | 29/01/2022 | Exeter City | - | Hartlepool United | 0:0 | ||||
| 32. Round | 12/02/2022 | Crawley Town | - | Hartlepool United | 0:1 | ||||
| 33. Round | 19/02/2022 | Hartlepool United | - | Sutton United | 1:1 | ||||
| 22. Round | 22/02/2022 | Colchester United | - | Hartlepool United | 1:2 |  |
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| 34. Round | 26/02/2022 | Walsall FC | - | Hartlepool United | 3:1 | ||||
| 36. Round | 12/03/2022 | Hartlepool United | - | Leyton Orient | 0:0 | ||||
| 37. Round | 15/03/2022 | Hartlepool United | - | Bradford City | 0:2 | ||||
| 38. Round | 18/03/2022 | Newport County | - | Hartlepool United | 2:3 | ||||
| 39. Round | 26/03/2022 | Northampton Town | - | Hartlepool United | 2:0 | ||||
| 30. Round | 29/03/2022 | Hartlepool United | - | Mansfield Town | 2:2 | ||||
| 40. Round | 02/04/2022 | Hartlepool United | - | Salford City | 0:2 | ||||
| 41. Round | 09/04/2022 | Forest Green Rovers | - | Hartlepool United | 1:1 | ||||
| 42. Round | 15/04/2022 | Hartlepool United | - | Port Vale FC | 0:1 | ||||
| 43. Round | 18/04/2022 | Rochdale AFC | - | Hartlepool United | 2:1 |
England