| 4. Round | 10/09/2021 | Everton FC U23 | - | Derby County U23 | 1:0 | ||||
| 7. Round | 02/10/2021 | Manchester City U23 | - | Derby County U23 | 1:0 |  |
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| 9. Round | 22/10/2021 | Derby County U23 | - | Crystal Palace U23 | 2:3 | ||||
| 10. Round | 30/10/2021 | Liverpool FC U23 | - | Derby County U23 | 3:1 | ||||
| 11. Round | 05/11/2021 | Derby County U23 | - | Blackburn Rovers U23 | 6:0 | |
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| 12. Round | 19/11/2021 | Derby County U23 | - | Manchester United U23 | 1:1 | ||||
| 13. Round | 26/11/2021 | Arsenal FC U23 | - | Derby County U23 | 3:5 | ||||
| 14. Round | 03/12/2021 | Derby County U23 | - | Chelsea FC U23 | 3:1 | ||||
| 16. Round | 10/01/2022 | Derby County U23 | - | Liverpool FC U23 | 0:1 | ||||
| 17. Round | 17/01/2022 | Leeds United U23 | - | Derby County U23 | 2:0 | ||||
| 18. Round | 21/01/2022 | Derby County U23 | - | Arsenal FC U23 | 1:1 |  |
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England