| 27. Round | 16/01/2022 | Hull City | - | Stoke City | 0:2 | ||||
| 28. Round | 22/01/2022 | Stoke City | - | Fulham FC | 2:3 | ||||
| 23. Round | 25/01/2022 | Coventry City | - | Stoke City | 1:0 | ||||
| 29. Round | 28/01/2022 | Huddersfield Town | - | Stoke City | 1:1 | ||||
| 35. Round | 26/02/2022 | AFC Bournemouth | - | Stoke City | 2:1 | ||||
| 36. Round | 05/03/2022 | Stoke City | - | Blackpool FC | 0:1 | ||||
| 24. Round | 08/03/2022 | Barnsley FC | - | Stoke City | 1:1 | ||||
| 37. Round | 12/03/2022 | Peterborough United | - | Stoke City | 2:2 | ||||
| 38. Round | 16/03/2022 | Cardiff City | - | Stoke City | 2:1 | ||||
| 39. Round | 19/03/2022 | Stoke City | - | Millwall FC | 2:0 | ||||
| 40. Round | 02/04/2022 | Stoke City | - | Sheffield United | 1:0 | ||||
| 30. Round | 05/04/2022 | Reading FC | - | Stoke City | 2:1 | ||||
| 41. Round | 09/04/2022 | West Bromwich Albion | - | Stoke City | 1:3 | ||||
| 42. Round | 15/04/2022 | Stoke City | - | Bristol City | 0:1 | ||||
| 43. Round | 18/04/2022 | Blackburn Rovers | - | Stoke City | 0:1 |
England