| 6. Round | 14/09/2024 | Reading FC | - | Leyton Orient | 0:1 | ||||
| 8. Round | 28/09/2024 | Leyton Orient | - | Wrexham AFC | 0:0 | ||||
| 9. Round | 01/10/2024 | Leyton Orient | - | Exeter City | 0:1 | ||||
| 10. Round | 05/10/2024 | Lincoln City | - | Leyton Orient | 2:1 |  |
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| 12. Round | 19/10/2024 | Northampton Town | - | Leyton Orient | 1:0 | ||||
| 15. Round | 09/11/2024 | Leyton Orient | - | Blackpool FC | 3:0 | ||||
| 11. Round | 26/11/2024 | Leyton Orient | - | Huddersfield Town | 0:2 | ||||
| 18. Round | 03/12/2024 | Leyton Orient | - | Bristol Rovers | 3:0 | ||||
| 21. Round | 21/12/2024 | Barnsley FC | - | Leyton Orient | 0:4 | ||||
| 22. Round | 26/12/2024 | Leyton Orient | - | Crawley Town | 3:0 | ||||
| 23. Round | 29/12/2024 | Leyton Orient | - | Cambridge United | 2:0 | ||||
| 25. Round | 04/01/2025 | Leyton Orient | - | Shrewsbury Town | 1:0 | ||||
| 27. Round | 18/01/2025 | Peterborough United | - | Leyton Orient | 0:0 | ||||
| 32. Round | 15/02/2025 | Leyton Orient | - | Lincoln City | 3:2 | ||||
| 31. Round | 18/02/2025 | Wrexham AFC | - | Leyton Orient | 1:2 | ||||
| 36. Round | 08/03/2025 | Leyton Orient | - | Northampton Town | 1:2 | |
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| 37. Round | 15/03/2025 | Blackpool FC | - | Leyton Orient | 1:2 |
England