| 1. Round | 08/08/2022 | Crystal Palace U21 | - | Brighton & Hove Albion U21 | 3:2 | ||||
| 2. Round | 14/08/2022 | Brighton & Hove Albion U21 | - | Liverpool FC U21 | 1:1 | ||||
| 5. Round | 03/09/2022 | Leicester City U21 | - | Brighton & Hove Albion U21 | 1:4 |  |
|||
| 7. Round | 18/09/2022 | Everton FC U21 | - | Brighton & Hove Albion U21 | 1:0 | ||||
| 8. Round | 30/09/2022 | Brighton & Hove Albion U21 | - | Tottenham Hotspur U21 | 4:0 | ||||
| 9. Round | 08/10/2022 | Manchester United U21 | - | Brighton & Hove Albion U21 | 3:3 | ||||
| 11. Round | 22/10/2022 | Brighton & Hove Albion U21 | - | West Ham United U21 | 3:2 | ||||
| 12. Round | 30/10/2022 | Brighton & Hove Albion U21 | - | Chelsea FC U21 | 2:2 | ||||
| 14. Round | 08/01/2023 | Brighton & Hove Albion U21 | - | Crystal Palace U21 | 2:4 | |
|||
| 17. Round | 30/01/2023 | Brighton & Hove Albion U21 | - | Leicester City U21 | 3:1 |  |
England