| 1. Round | 16/08/2021 | West Bromwich Albion U23 | - | Burnley FC U23 | 3:2 |  |
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| 3. Round | 27/08/2021 | Newcastle United U23 | - | Burnley FC U23 | 2:0 | ||||
| 4. Round | 10/09/2021 | Burnley FC U23 | - | Wolverhampton Wanderers U23 | 1:1 | ||||
| 7. Round | 01/10/2021 | Nottingham Forest U23 | - | Burnley FC U23 | 1:1 | ||||
| 8. Round | 15/10/2021 | Burnley FC U23 | - | Norwich City U23 | 4:3 |  |
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| 9. Round | 22/10/2021 | Burnley FC U23 | - | Middlesbrough FC U23 | 2:0 | ||||
| 10. Round | 01/11/2021 | Birmingham City U23 | - | Burnley FC U23 | 1:2 | ||||
| 11. Round | 08/11/2021 | Burnley FC U23 | - | Fulham FC U23 | 1:2 | ||||
| 12. Round | 22/11/2021 | Aston Villa U23 | - | Burnley FC U23 | 4:1 | |
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| 13. Round | 26/11/2021 | Burnley FC U23 | - | Stoke City U23 | 0:1 | ||||
| 14. Round | 10/12/2021 | Burnley FC U23 | - | Nottingham Forest U23 | 1:1 |  |
England