| 1. Round | 07/08/2021 | Shrewsbury Town | - | Burton Albion | 0:1 | ||||
| 9. Round | 25/09/2021 | Burton Albion | - | Lincoln City | 1:2 | ||||
| 10. Round | 28/09/2021 | Burton Albion | - | Portsmouth FC | 2:1 | ||||
| 11. Round | 02/10/2021 | AFC Wimbledon | - | Burton Albion | 1:1 | ||||
| 12. Round | 09/10/2021 | Plymouth Argyle | - | Burton Albion | 2:1 | ||||
| 18. Round | 20/11/2021 | Milton Keynes Dons | - | Burton Albion | 1:0 | ||||
| 21. Round | 07/12/2021 | Wycombe Wanderers | - | Burton Albion | 2:1 |  |
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| 26. Round | 01/01/2022 | Burton Albion | - | Crewe Alexandra | 4:1 | ||||
| 27. Round | 08/01/2022 | Cheltenham Town | - | Burton Albion | 1:1 | ||||
| 23. Round | 25/01/2022 | Burton Albion | - | Milton Keynes Dons | 0:1 | ||||
| 31. Round | 05/02/2022 | Burton Albion | - | Sheffield Wednesday | 0:2 | ||||
| 34. Round | 19/02/2022 | Ipswich Town | - | Burton Albion | 3:0 | ||||
| 37. Round | 05/03/2022 | Oxford United | - | Burton Albion | 4:1 | ||||
| 42. Round | 09/04/2022 | Burton Albion | - | Plymouth Argyle | 0:0 | |
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| 46. Round | 30/04/2022 | Burton Albion | - | Wycombe Wanderers | 1:2 |
England