| 2. Round | 23/08/2021 | Reading FC U23 | - | Wolverhampton Wanderers U23 | 3:0 |  |
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| 3. Round | 29/08/2021 | Stoke City U23 | - | Reading FC U23 | 1:2 | ||||
| 4. Round | 12/09/2021 | Reading FC U23 | - | Nottingham Forest U23 | 0:2 | ||||
| 5. Round | 20/09/2021 | Reading FC U23 | - | Norwich City U23 | 3:3 | ||||
| 6. Round | 27/09/2021 | Burnley FC U23 | - | Reading FC U23 | 3:1 | ||||
| 9. Round | 25/10/2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
| 11. Round | 08/11/2021 | Reading FC U23 | - | Aston Villa U23 | 2:2 |  |
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| 18. Round | 24/01/2022 | Aston Villa U23 | - | Reading FC U23 | 4:1 | |
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| 20. Round | 21/02/2022 | Nottingham Forest U23 | - | Reading FC U23 | 7:0 | ||||
| 21. Round | 28/02/2022 | Wolverhampton Wanderers U23 | - | Reading FC U23 | 4:3 | |
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| 23. Round | 20/03/2022 | Southampton FC U23 | - | Reading FC U23 | 2:1 | |
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| 24. Round | 01/04/2022 | Reading FC U23 | - | West Bromwich Albion U23 | 1:1 |
England