| 1. Round | 16/08/2021 | Crystal Palace U23 | - | Leeds United U23 | 1:3 |  |
 |
||
| 2. Round | 20/08/2021 | Arsenal FC U23 | - | Crystal Palace U23 | 4:2 | ||||
| 3. Round | 27/08/2021 | Crystal Palace U23 | - | Everton FC U23 | 3:1 | |
|||
| 4. Round | 13/09/2021 | Leicester City U23 | - | Crystal Palace U23 | 1:6 | ||||
| 5. Round | 18/09/2021 | Manchester City U23 | - | Crystal Palace U23 | 4:2 | |
|||
| 6. Round | 24/09/2021 | West Ham United U23 | - | Crystal Palace U23 | 1:0 | ||||
| 7. Round | 01/10/2021 | Crystal Palace U23 | - | Tottenham Hotspur U23 | 4:3 | ||||
| 8. Round | 16/10/2021 | Brighton & Hove Albion U23 | - | Crystal Palace U23 | 2:1 | |
|||
| 9. Round | 22/10/2021 | Derby County U23 | - | Crystal Palace U23 | 2:3 | ||||
| 10. Round | 01/11/2021 | Crystal Palace U23 | - | Blackburn Rovers U23 | 1:2 | ||||
| 11. Round | 06/11/2021 | Chelsea FC U23 | - | Crystal Palace U23 | 1:2 | |
|||
| 12. Round | 20/11/2021 | Liverpool FC U23 | - | Crystal Palace U23 | 0:3 | ||||
| 13. Round | 27/11/2021 | Manchester United U23 | - | Crystal Palace U23 | 1:2 | ||||
| 14. Round | 06/12/2021 | Crystal Palace U23 | - | West Ham United U23 | 2:4 |
Ireland