| 1. Round | 08/08/2022 | Nottingham Forest U21 | - | Southampton FC U21 | 1:3 | ||||
| 3. Round | 19/08/2022 | Stoke City U21 | - | Southampton FC U21 | 0:3 | ||||
| 4. Round | 26/08/2022 | Southampton FC U21 | - | Norwich City U21 | 1:1 |  |
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| 13. Round | 13/01/2023 | Southampton FC U21 | - | Newcastle United U21 | 4:1 |
England