| 1. Round | 30/07/2022 | Sheffield Wednesday | - | Portsmouth FC | 3:3 | ||||
| 2. Round | 06/08/2022 | Portsmouth FC | - | Lincoln City | 0:0 | ||||
| 3. Round | 13/08/2022 | Cheltenham Town | - | Portsmouth FC | 0:2 | ||||
| 4. Round | 16/08/2022 | Portsmouth FC | - | Cambridge United | 4:1 | ||||
| 6. Round | 27/08/2022 | Port Vale FC | - | Portsmouth FC | 0:1 | ||||
| 7. Round | 03/09/2022 | Portsmouth FC | - | Peterborough United | 2:1 | ||||
| 9. Round | 13/09/2022 | Burton Albion | - | Portsmouth FC | 0:2 | ||||
| 14. Round | 08/10/2022 | Portsmouth FC | - | Fleetwood Town | 1:1 | ||||
| 15. Round | 17/10/2022 | Charlton Athletic | - | Portsmouth FC | 3:0 | ||||
| 16. Round | 22/10/2022 | Forest Green Rovers | - | Portsmouth FC | 0:1 | ||||
| 13. Round | 25/10/2022 | Portsmouth FC | - | Oxford United | 1:1 | ||||
| 17. Round | 29/10/2022 | Portsmouth FC | - | Shrewsbury Town | 1:1 |  |
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| 18. Round | 12/11/2022 | Morecambe FC | - | Portsmouth FC | 1:1 | |
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| 19. Round | 18/11/2022 | Portsmouth FC | - | Derby County | 0:0 | ||||
| 20. Round | 04/12/2022 | Wycombe Wanderers | - | Portsmouth FC | 2:0 | ||||
| 22. Round | 17/12/2022 | Portsmouth FC | - | Milton Keynes Dons | 0:2 | ||||
| 25. Round | 01/01/2023 | Portsmouth FC | - | Charlton Athletic | 1:3 |
England