1. Round | 07/08/2021 | Salford City | - | Leyton Orient | 1:1 | ||||
2. Round | 14/08/2021 | Leyton Orient | - | Exeter City | 3:0 | ||||
4. Round | 21/08/2021 | Carlisle United | - | Leyton Orient | 1:1 | ||||
22. Round | 18/12/2021 | Tranmere Rovers | - | Leyton Orient | 1:0 | ||||
41. Round | 09/04/2022 | Sutton United | - | Leyton Orient | 1:0 |