| 23. Round | 03/02/2021 | AS Monaco | - | OGC Nice | 2:1 |  |
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| 24. Round | 07/02/2021 | OGC Nice | - | Angers SCO | 3:0 | |
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| 25. Round | 13/02/2021 | Paris Saint-Germain | - | OGC Nice | 2:1 | ||||
| 26. Round | 21/02/2021 | OGC Nice | - | FC Metz | 1:2 | ||||
| 27. Round | 26/02/2021 | Stade Rennais | - | OGC Nice | 1:2 | |
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| 28. Round | 03/03/2021 | OGC Nice | - | Nîmes Olympique | 2:1 | ||||
| 30. Round | 20/03/2021 | OGC Nice | - | Olympique Marseille | 3:0 | ||||
| 31. Round | 04/04/2021 | FC Nantes | - | OGC Nice | 1:2 | ||||
| 32. Round | 11/04/2021 | OGC Nice | - | Stade de Reims | 0:0 | ||||
| 33. Round | 18/04/2021 | Dijon FCO | - | OGC Nice | 2:0 | ||||
| 34. Round | 25/04/2021 | OGC Nice | - | Montpellier HSC | 3:1 |  |
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| 35. Round | 01/05/2021 | Lille OSC | - | OGC Nice | 2:0 | ||||
| 36. Round | 09/05/2021 | OGC Nice | - | Stade Brestois 29 | 3:2 | |
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| 37. Round | 16/05/2021 | OGC Nice | - | RC Strasbourg | 0:2 | ||||
| 38. Round | 23/05/2021 | Olympique Lyonnais | - | OGC Nice | 2:3 | |
French Guyana
