| 1. Round | 07/08/2010 | Walsall FC | - | Milton Keynes Dons | 1:2 | ||||
| 3. Round | 21/08/2010 | Carlisle United | - | Milton Keynes Dons | 4:1 | ||||
| 4. Round | 28/08/2010 | Milton Keynes Dons | - | Swindon Town | 2:1 | ||||
| 5. Round | 04/09/2010 | Milton Keynes Dons | - | Hartlepool United | 1:0 | ||||
| 6. Round | 11/09/2010 | Brighton & Hove Albion | - | Milton Keynes Dons | 2:0 | ||||
| 2. Round | 15/09/2010 | Milton Keynes Dons | - | Southampton FC | 2:0 | ||||
| 7. Round | 18/09/2010 | Milton Keynes Dons | - | Rochdale AFC | 1:1 | ||||
| 8. Round | 25/09/2010 | Peterborough United | - | Milton Keynes Dons | 2:1 | ||||
| 9. Round | 28/09/2010 | Charlton Athletic | - | Milton Keynes Dons | 1:0 | ||||
| 10. Round | 02/10/2010 | Milton Keynes Dons | - | Colchester United | 1:1 | ||||
| 11. Round | 09/10/2010 | Milton Keynes Dons | - | Dagenham & Redbridge | 2:0 | ||||
| 12. Round | 16/10/2010 | AFC Bournemouth | - | Milton Keynes Dons | 3:2 |  |
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| 13. Round | 23/10/2010 | Milton Keynes Dons | - | Exeter City | 1:0 | ||||
| 15. Round | 02/11/2010 | Milton Keynes Dons | - | Yeovil Town | 3:2 |
Wales
