| 7. Round | 11/09/2021 | Shrewsbury Town | - | Crewe Alexandra | 1:1 | ||||
| 8. Round | 18/09/2021 | Crewe Alexandra | - | Burton Albion | 2:0 |  |
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| 6. Round | 21/09/2021 | Crewe Alexandra | - | Morecambe FC | 1:3 | ||||
| 10. Round | 28/09/2021 | Plymouth Argyle | - | Crewe Alexandra | 1:1 | ||||
| 11. Round | 02/10/2021 | Crewe Alexandra | - | Cambridge United | 2:2 | ||||
| 13. Round | 16/10/2021 | Fleetwood Town | - | Crewe Alexandra | 3:0 | ||||
| 14. Round | 19/10/2021 | Crewe Alexandra | - | Sunderland AFC | 0:4 | ||||
| 16. Round | 30/10/2021 | Crewe Alexandra | - | Milton Keynes Dons | 1:4 |  |
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| 12. Round | 02/11/2021 | Crewe Alexandra | - | Doncaster Rovers | 1:1 |
England