| 2. Round | 02/05/2022 | Houston Dash [Women] | - | San Diego Wave FC [Women] | 0:1 |  |
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| 2. Round | 08/05/2022 | San Diego Wave FC [Women] | - | NJ/NY Gotham FC [Women] | 4:0 | ||||
| 2. Round | 15/05/2022 | San Diego Wave FC [Women] | - | Chicago Red Stars [Women] | 2:1 |  |
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| 2. Round | 22/05/2022 | NC Courage [Women] | - | San Diego Wave FC [Women] | 0:1 | ||||
| 2. Round | 29/05/2022 | OL Reign [Women] | - | San Diego Wave FC [Women] | 1:0 | ||||
| 3. Round | 05/06/2022 | Kansas City Current [Women] | - | San Diego Wave FC [Women] | 2:2 | ||||
| 3. Round | 09/06/2022 | San Diego Wave FC [Women] | - | Portland Thorns [Women] | 2:2 | ||||
| 3. Round | 12/06/2022 | San Diego Wave FC [Women] | - | OL Reign [Women] | 1:1 | ||||
| 3. Round | 19/06/2022 | NJ/NY Gotham FC [Women] | - | San Diego Wave FC [Women] | 0:3 | |
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| 6. Round | 10/09/2022 | Washington Spirit [Women] | - | San Diego Wave FC [Women] | 4:3 | ||||
| 6. Round | 18/09/2022 | San Diego Wave FC [Women] | - | Angel City FC [Women] | 1:0 | ||||
| 6. Round | 26/09/2022 | Orlando Pride [Women] | - | San Diego Wave FC [Women] | 2:2 | |
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| 6. Round | 01/10/2022 | San Diego Wave FC [Women] | - | NC Courage [Women] | 0:0 |
England