| 2. Round | 14/08/2010 | Huddersfield Town | - | Tranmere Rovers | 0:0 | ||||
| 3. Round | 21/08/2010 | Tranmere Rovers | - | AFC Bournemouth | 0:3 | ||||
| 4. Round | 28/08/2010 | Dagenham & Redbridge | - | Tranmere Rovers | 2:2 | ||||
| 5. Round | 04/09/2010 | Tranmere Rovers | - | Peterborough United | 1:0 | ||||
| 6. Round | 11/09/2010 | Yeovil Town | - | Tranmere Rovers | 3:1 | ||||
| 24. Round | 01/01/2011 | Rochdale AFC | - | Tranmere Rovers | 3:2 | ||||
| 25. Round | 03/01/2011 | Tranmere Rovers | - | Carlisle United | 2:1 |
England