| 21. Round | 28/02/2022 | Wolverhampton Wanderers U23 | - | Reading FC U23 | 4:3 | ||||
| 22. Round | 14/03/2022 | West Bromwich Albion U23 | - | Wolverhampton Wanderers U23 | 0:4 |  |
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| 23. Round | 18/03/2022 | Wolverhampton Wanderers U23 | - | Aston Villa U23 | 3:0 | ||||
| 16. Round | 25/03/2022 | Southampton FC U23 | - | Wolverhampton Wanderers U23 | 2:4 | ||||
| 24. Round | 01/04/2022 | Nottingham Forest U23 | - | Wolverhampton Wanderers U23 | 1:0 | ||||
| 20. Round | 15/04/2022 | Middlesbrough FC U23 | - | Wolverhampton Wanderers U23 | 0:3 | ||||
| 25. Round | 25/04/2022 | Wolverhampton Wanderers U23 | - | Stoke City U23 | 2:2 | |
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| 26. Round | 29/04/2022 | Norwich City U23 | - | Wolverhampton Wanderers U23 | 0:2 |  |
England