| 11. Round | 22/10/2022 | Manchester United U21 | - | Wolverhampton Wanderers U21 | 3:2 |  |
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| 14. Round | 06/01/2023 | Fulham FC U21 | - | Manchester United U21 | 1:2 | |
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| 15. Round | 14/01/2023 | Manchester United U21 | - | Liverpool FC U21 | 2:1 | |
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| 16. Round | 20/01/2023 | West Ham United U21 | - | Manchester United U21 | 2:3 | |
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| 17. Round | 27/01/2023 | Manchester United U21 | - | Blackburn Rovers U21 | 2:1 |  |
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| 18. Round | 11/02/2023 | Manchester United U21 | - | Everton FC U21 | 4:1 | |
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| 19. Round | 20/02/2023 | Crystal Palace U21 | - | Manchester United U21 | 0:0 | ||||
| 20. Round | 24/02/2023 | Wolverhampton Wanderers U21 | - | Manchester United U21 | 2:2 | |
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| 21. Round | 06/03/2023 | Manchester United U21 | - | Chelsea FC U21 | 1:3 | |
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| 25. Round | 21/04/2023 | Brighton & Hove Albion U21 | - | Manchester United U21 | 3:2 | |
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| 26. Round | 28/04/2023 | Manchester United U21 | - | Tottenham Hotspur U21 | 2:2 | |
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| 6. Round | 05/05/2023 | Manchester United U21 | - | Leicester City U21 | 2:2 |
England