| 1. Round | 16/08/2021 | Blackburn Rovers U23 | - | Everton FC U23 | 2:2 | ||||
| 2. Round | 20/08/2021 | Manchester City U23 | - | Blackburn Rovers U23 | 4:2 | ||||
| 3. Round | 27/08/2021 | Blackburn Rovers U23 | - | Leicester City U23 | 1:1 |  |
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| 4. Round | 10/09/2021 | Brighton & Hove Albion U23 | - | Blackburn Rovers U23 | 4:1 | ||||
| 6. Round | 24/09/2021 | Leeds United U23 | - | Blackburn Rovers U23 | 4:4 | ||||
| 7. Round | 03/10/2021 | Chelsea FC U23 | - | Blackburn Rovers U23 | 0:1 | ||||
| 8. Round | 16/10/2021 | Manchester United U23 | - | Blackburn Rovers U23 | 3:0 | ||||
| 10. Round | 01/11/2021 | Crystal Palace U23 | - | Blackburn Rovers U23 | 1:2 | ||||
| 11. Round | 05/11/2021 | Derby County U23 | - | Blackburn Rovers U23 | 6:0 | ||||
| 12. Round | 22/11/2021 | Blackburn Rovers U23 | - | Arsenal FC U23 | 2:3 | ||||
| 13. Round | 26/11/2021 | West Ham United U23 | - | Blackburn Rovers U23 | 1:0 | ||||
| 14. Round | 05/12/2021 | Blackburn Rovers U23 | - | Manchester United U23 | 0:4 | ||||
| 22. Round | 14/03/2022 | Arsenal FC U23 | - | Blackburn Rovers U23 | 2:2 |
England