| 30. Round | 05/02/2022 | Scunthorpe United | - | Oldham Athletic | 0:1 | ||||
| 31. Round | 08/02/2022 | Scunthorpe United | - | Walsall FC | 1:0 | ||||
| 32. Round | 12/02/2022 | Swindon Town | - | Scunthorpe United | 3:0 | ||||
| 33. Round | 19/02/2022 | Scunthorpe United | - | Rochdale AFC | 1:2 | ||||
| 24. Round | 22/02/2022 | Scunthorpe United | - | Northampton Town | 0:0 |  |
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| 34. Round | 26/02/2022 | Sutton United | - | Scunthorpe United | 4:1 | |
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| 35. Round | 05/03/2022 | Crawley Town | - | Scunthorpe United | 0:0 | ||||
| 36. Round | 12/03/2022 | Scunthorpe United | - | Colchester United | 1:3 |  |
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| 37. Round | 15/03/2022 | Scunthorpe United | - | Barrow AFC | 0:1 | ||||
| 38. Round | 19/03/2022 | Salford City | - | Scunthorpe United | 5:1 | |
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| 39. Round | 26/03/2022 | Scunthorpe United | - | Harrogate Town | 0:3 | ||||
| 40. Round | 02/04/2022 | Forest Green Rovers | - | Scunthorpe United | 1:0 | ||||
| 41. Round | 09/04/2022 | Scunthorpe United | - | Mansfield Town | 0:4 | ||||
| 43. Round | 18/04/2022 | Scunthorpe United | - | Stevenage FC | 1:1 | ||||
| 45. Round | 30/04/2022 | Scunthorpe United | - | Hartlepool United | 1:1 | |
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| 46. Round | 07/05/2022 | Bristol Rovers | - | Scunthorpe United | 7:0 | |
England