| 20. Round | 27/01/2001 | Royal Antwerp FC | - | RSC Charleroi | 1:1 | ||||
| 21. Round | 04/02/2001 | KRC Harelbeke | - | Royal Antwerp FC | 2:0 | ||||
| 22. Round | 09/02/2001 | RSC Anderlecht | - | Royal Antwerp FC | 2:0 | ||||
| 24. Round | 03/03/2001 | KRC Genk | - | Royal Antwerp FC | 1:1 |  |
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| 25. Round | 11/03/2001 | Royal Antwerp FC | - | KAA Gent | 1:0 | ||||
| 26. Round | 17/03/2001 | Excelsior Mouscron | - | Royal Antwerp FC | 3:2 | ||||
| 27. Round | 31/03/2001 | Royal Antwerp FC | - | Sporting Lokeren | 2:1 | ||||
| 28. Round | 07/04/2001 | Standard Liège | - | Royal Antwerp FC | 0:1 | ||||
| 29. Round | 14/04/2001 | Royal Antwerp FC | - | RAA La Louviére | 1:1 | ||||
| 30. Round | 22/04/2001 | Germinal Beerschot | - | Royal Antwerp FC | 3:1 | ||||
| 31. Round | 29/04/2001 | Royal Antwerp FC | - | Club Brugge KV | 0:1 | ||||
| 32. Round | 04/05/2001 | KV Mechelen | - | Royal Antwerp FC | 0:3 | ||||
| 33. Round | 12/05/2001 | Royal Antwerp FC | - | K.S.C. Eendracht Aalst | 0:0 | ||||
| 34. Round | 20/05/2001 | Sint-Truidense VV | - | Royal Antwerp FC | 1:1 |
Ireland
