| 1. Round | 16/08/2021 | Sunderland AFC U23 | - | Fulham FC U23 | 3:4 | ||||
| 2. Round | 20/08/2021 | Fulham FC U23 | - | West Bromwich Albion U23 | 3:0 |  |
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| 8. Round | 15/10/2021 | Fulham FC U23 | - | Reading FC U23 | 3:0 |  |
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| 9. Round | 22/10/2021 | Fulham FC U23 | - | Nottingham Forest U23 | 2:1 | ||||
| 10. Round | 01/11/2021 | Fulham FC U23 | - | Middlesbrough FC U23 | 2:0 | ||||
| 15. Round | 20/12/2021 | West Bromwich Albion U23 | - | Fulham FC U23 | 2:4 | ||||
| 17. Round | 17/01/2022 | Southampton FC U23 | - | Fulham FC U23 | 2:1 | ||||
| 18. Round | 24/01/2022 | Stoke City U23 | - | Fulham FC U23 | 0:1 | ||||
| 13. Round | 30/01/2022 | Birmingham City U23 | - | Fulham FC U23 | 1:3 | ||||
| 19. Round | 04/02/2022 | Fulham FC U23 | - | Sunderland AFC U23 | 2:0 | ||||
| 20. Round | 21/02/2022 | Newcastle United U23 | - | Fulham FC U23 | 1:6 | ||||
| 24. Round | 01/04/2022 | Fulham FC U23 | - | Birmingham City U23 | 3:0 | ||||
| 25. Round | 25/04/2022 | Reading FC U23 | - | Fulham FC U23 | 3:1 | ||||
| 26. Round | 29/04/2022 | Fulham FC U23 | - | Burnley FC U23 | 5:3 |
England