| 6. Round | 04/09/2021 | Oldham Athletic | - | Barrow AFC | 0:3 | ||||
| 7. Round | 10/09/2021 | Barrow AFC | - | Colchester United | 2:3 |  |
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| 8. Round | 18/09/2021 | Bradford City | - | Barrow AFC | 1:1 |  |
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| 9. Round | 24/09/2021 | Barrow AFC | - | Newport County | 2:1 | ||||
| 10. Round | 02/10/2021 | Mansfield Town | - | Barrow AFC | 0:1 | ||||
| 11. Round | 09/10/2021 | Barrow AFC | - | Leyton Orient | 1:1 | ||||
| 12. Round | 16/10/2021 | Port Vale FC | - | Barrow AFC | 3:1 | ||||
| 13. Round | 19/10/2021 | Barrow AFC | - | Scunthorpe United | 1:1 | ||||
| 14. Round | 23/10/2021 | Walsall FC | - | Barrow AFC | 2:2 | |
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| 16. Round | 13/11/2021 | Carlisle United | - | Barrow AFC | 0:0 | |
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| 19. Round | 27/11/2021 | Sutton United | - | Barrow AFC | 1:0 | ||||
| 21. Round | 11/12/2021 | Barrow AFC | - | Swindon Town | 2:0 | ||||
| 23. Round | 26/12/2021 | Tranmere Rovers | - | Barrow AFC | 2:0 | ||||
| 24. Round | 29/12/2021 | Barrow AFC | - | Oldham Athletic | 0:0 | ||||
| 25. Round | 01/01/2022 | Barrow AFC | - | Bradford City | 1:2 | ||||
| 20. Round | 25/01/2022 | Barrow AFC | - | Salford City | 0:2 | ||||
| 35. Round | 05/03/2022 | Barrow AFC | - | Walsall FC | 1:1 | ||||
| 38. Round | 19/03/2022 | Barrow AFC | - | Carlisle United | 1:2 | ||||
| 46. Round | 07/05/2022 | Barrow AFC | - | Northampton Town | 1:3 |
England