| 2. Round | 14/08/2021 | Oxford United | - | Charlton Athletic | 2:1 | ||||
| 4. Round | 21/08/2021 | Charlton Athletic | - | Wigan Athletic | 0:2 | ||||
| 8. Round | 18/09/2021 | Wycombe Wanderers | - | Charlton Athletic | 2:1 | ||||
| 6. Round | 21/09/2021 | Gillingham FC | - | Charlton Athletic | 1:1 | ||||
| 9. Round | 25/09/2021 | Charlton Athletic | - | Portsmouth FC | 2:2 |  |
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| 10. Round | 28/09/2021 | Charlton Athletic | - | Bolton Wanderers | 1:4 | |
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| 11. Round | 02/10/2021 | Fleetwood Town | - | Charlton Athletic | 1:2 | ||||
| 13. Round | 16/10/2021 | Lincoln City | - | Charlton Athletic | 2:1 | ||||
| 14. Round | 19/10/2021 | Charlton Athletic | - | Accrington Stanley | 2:3 | ||||
| 16. Round | 30/10/2021 | Charlton Athletic | - | Doncaster Rovers | 4:0 | ||||
| 17. Round | 13/11/2021 | Burton Albion | - | Charlton Athletic | 0:1 | ||||
| 18. Round | 20/11/2021 | Charlton Athletic | - | Plymouth Argyle | 2:0 | ||||
| 19. Round | 23/11/2021 | Morecambe FC | - | Charlton Athletic | 2:2 | ||||
| 20. Round | 27/11/2021 | Shrewsbury Town | - | Charlton Athletic | 1:0 | ||||
| 26. Round | 01/01/2022 | Charlton Athletic | - | Wycombe Wanderers | 0:1 |
England