| 6. Round | 11/09/2021 | Bristol City | - | Preston North End | 0:0 | ||||
| 7. Round | 14/09/2021 | Sheffield United | - | Preston North End | 2:2 | ||||
| 8. Round | 18/09/2021 | Preston North End | - | West Bromwich Albion | 1:1 | ||||
| 9. Round | 25/09/2021 | Birmingham City | - | Preston North End | 0:0 | ||||
| 10. Round | 28/09/2021 | Preston North End | - | Stoke City | 1:1 | ||||
| 12. Round | 16/10/2021 | Preston North End | - | Derby County | 0:0 | ||||
| 13. Round | 20/10/2021 | Preston North End | - | Coventry City | 2:1 | ||||
| 36. Round | 05/03/2022 | Preston North End | - | AFC Bournemouth | 2:1 | ||||
| 38. Round | 16/03/2022 | Luton Town | - | Preston North End | 4:0 | ||||
| 40. Round | 02/04/2022 | Derby County | - | Preston North End | 1:0 | ||||
| 41. Round | 09/04/2022 | Preston North End | - | Queens Park Rangers | 2:1 | ||||
| 42. Round | 15/04/2022 | Preston North End | - | Millwall FC | 1:1 |
England