| 7. Round | 23/10/2021 | Leeds United [U18] | - | Stoke City [U18] | 0:2 |  |
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| 8. Round | 30/10/2021 | Middlesbrough FC [U18] | - | Stoke City [U18] | 1:1 | ||||
| 9. Round | 05/11/2021 | Stoke City [U18] | - | Burnley FC [U18] | 1:3 | ||||
| 10. Round | 20/11/2021 | Derby County [U18] | - | Stoke City [U18] | 2:1 |  |
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| 11. Round | 04/12/2021 | Stoke City [U18] | - | Manchester City [U18] | 2:0 | ||||
| 12. Round | 18/12/2021 | Stoke City [U18] | - | Wolverhampton Wanderers [U18] | 0:4 | ||||
| 13. Round | 08/01/2022 | Everton FC [U18] | - | Stoke City [U18] | 2:2 | ||||
| 14. Round | 15/01/2022 | Stoke City [U18] | - | Derby County [U18] | 3:0 | ||||
| 15. Round | 22/01/2022 | Manchester City [U18] | - | Stoke City [U18] | 5:0 | |
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| 16. Round | 05/02/2022 | Stoke City [U18] | - | Middlesbrough FC [U18] | 1:2 | ||||
| 18. Round | 26/02/2022 | Burnley FC [U18] | - | Stoke City [U18] | 3:1 | ||||
| 19. Round | 05/03/2022 | Stoke City [U18] | - | Liverpool FC [U18] | 0:2 | ||||
| 25. Round | 30/04/2022 | Stoke City [U18] | - | Leeds United [U18] | 1:3 |
England