| 19. Round | 23/11/2021 | Sheffield Wednesday | - | Milton Keynes Dons | 2:1 |  |
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| 20. Round | 27/11/2021 | Sheffield Wednesday | - | Wycombe Wanderers | 2:2 | |
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| 22. Round | 11/12/2021 | Crewe Alexandra | - | Sheffield Wednesday | 0:2 | ||||
| 28. Round | 15/01/2022 | Sheffield Wednesday | - | Plymouth Argyle | 4:2 | |
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| 29. Round | 22/01/2022 | Oxford United | - | Sheffield Wednesday | 3:2 | |
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| 30. Round | 29/01/2022 | Sheffield Wednesday | - | Ipswich Town | 1:0 | ||||
| 27. Round | 01/02/2022 | Sheffield Wednesday | - | Morecambe FC | 2:0 | ||||
| 35. Round | 26/04/2022 | Fleetwood Town | - | Sheffield Wednesday | 2:3 | ||||
| 46. Round | 30/04/2022 | Sheffield Wednesday | - | Portsmouth FC | 4:1 |
England