| 1. Round | 14/08/2021 | Norwich City [U18] | - | Southampton FC [U18] | 0:2 | ||||
| 2. Round | 21/08/2021 | Southampton FC [U18] | - | Birmingham City [U18] | 7:2 | ||||
| 3. Round | 28/08/2021 | West Ham United [U18] | - | Southampton FC [U18] | 1:3 | ||||
| 4. Round | 11/09/2021 | Southampton FC [U18] | - | Arsenal FC [U18] | 3:3 |  |
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| 7. Round | 23/10/2021 | West Bromwich Albion [U18] | - | Southampton FC [U18] | 1:5 | ||||
| 8. Round | 30/10/2021 | Southampton FC [U18] | - | Brighton & Hove Albion [U18] | 3:2 | ||||
| 9. Round | 06/11/2021 | Southampton FC [U18] | - | Aston Villa [U18] | 6:3 | ||||
| 10. Round | 20/11/2021 | Tottenham Hotspur [U18] | - | Southampton FC [U18] | 0:3 | ||||
| 11. Round | 04/12/2021 | Southampton FC [U18] | - | Fulham FC [U18] | 2:0 | ||||
| 14. Round | 15/01/2022 | Southampton FC [U18] | - | Tottenham Hotspur [U18] | 1:2 | ||||
| 26. Round | 07/05/2022 | Southampton FC [U18] | - | Chelsea FC [U18] | 5:2 |
England