| 5. Round | 19/09/2021 | Southampton FC U23 | - | Burnley FC U23 | 0:2 | ||||
| 6. Round | 27/09/2021 | Birmingham City U23 | - | Southampton FC U23 | 3:2 | ||||
| 7. Round | 01/10/2021 | Southampton FC U23 | - | Stoke City U23 | 1:1 | ||||
| 8. Round | 18/10/2021 | Wolverhampton Wanderers U23 | - | Southampton FC U23 | 0:1 |
England