| 6. Round | 04/09/2021 | Accrington Stanley | - | Shrewsbury Town | 1:0 | ||||
| 7. Round | 11/09/2021 | Sunderland AFC | - | Accrington Stanley | 2:1 | ||||
| 8. Round | 18/09/2021 | Accrington Stanley | - | Wigan Athletic | 1:4 | ||||
| 13. Round | 16/10/2021 | Cheltenham Town | - | Accrington Stanley | 1:0 | ||||
| 17. Round | 13/11/2021 | Accrington Stanley | - | Plymouth Argyle | 1:4 | ||||
| 18. Round | 20/11/2021 | Accrington Stanley | - | Sheffield Wednesday | 2:3 | ||||
| 19. Round | 23/11/2021 | Burton Albion | - | Accrington Stanley | 4:0 | ||||
| 12. Round | 04/12/2021 | Accrington Stanley | - | Fleetwood Town | 5:1 | ||||
| 22. Round | 11/12/2021 | Accrington Stanley | - | Bolton Wanderers | 1:0 | ||||
| 24. Round | 26/12/2021 | Accrington Stanley | - | Rotherham United | 1:0 |
England