| Group A South | 07/09/2021 | Colchester United | - | Gillingham FC | 0:1 | ||||
| Group A South | 28/09/2021 | Colchester United | - | West Ham United U23 | 1:0 |  |
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| Group A South | 09/11/2021 | Ipswich Town | - | Colchester United | 4:3 pso | ||||
| 2. Round | 30/11/2021 | Swindon Town | - | Colchester United | 1:2 | ||||
| Round of 16 | 04/01/2022 | Sutton United | - | Colchester United | 2:1 |
England