| 2. Round | 23/08/2021 | Everton FC U23 | - | Liverpool FC U23 | 1:3 |  |
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| 3. Round | 28/08/2021 | Liverpool FC U23 | - | Brighton & Hove Albion U23 | 1:1 | ||||
| 4. Round | 11/09/2021 | Tottenham Hotspur U23 | - | Liverpool FC U23 | 2:1 | |
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| 13. Round | 28/11/2021 | Liverpool FC U23 | - | Leicester City U23 | 3:0 | ||||
| 14. Round | 03/12/2021 | Brighton & Hove Albion U23 | - | Liverpool FC U23 | 3:0 | ||||
| 18. Round | 24/01/2022 | Crystal Palace U23 | - | Liverpool FC U23 | 0:2 | |
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| 19. Round | 07/02/2022 | Leeds United U23 | - | Liverpool FC U23 | 3:0 |
England