| 3. Round | 27/08/2021 | Tottenham Hotspur U23 | - | Arsenal FC U23 | 1:2 | ||||
| 5. Round | 19/09/2021 | Chelsea FC U23 | - | Arsenal FC U23 | 1:6 | ||||
| 7. Round | 01/10/2021 | Arsenal FC U23 | - | Brighton & Hove Albion U23 | 3:0 | ||||
| 10. Round | 29/10/2021 | Leeds United U23 | - | Arsenal FC U23 | 2:4 | ||||
| 11. Round | 06/11/2021 | Arsenal FC U23 | - | Leicester City U23 | 3:3 | ||||
| 17. Round | 14/01/2022 | Arsenal FC U23 | - | West Ham United U23 | 1:1 |
Estonia