| 6. Round | 27/09/2021 | Burnley FC U23 | - | Reading FC U23 | 3:1 | ||||
| 8. Round | 15/10/2021 | Fulham FC U23 | - | Reading FC U23 | 3:0 | ||||
| 9. Round | 25/10/2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
| 10. Round | 01/11/2021 | Reading FC U23 | - | Sunderland AFC U23 | 0:3 | ||||
| 11. Round | 08/11/2021 | Reading FC U23 | - | Aston Villa U23 | 2:2 | ||||
| 12. Round | 22/11/2021 | West Bromwich Albion U23 | - | Reading FC U23 | 1:1 |  |
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| 14. Round | 03/12/2021 | Norwich City U23 | - | Reading FC U23 | 5:2 |  |
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| 18. Round | 24/01/2022 | Aston Villa U23 | - | Reading FC U23 | 4:1 | ||||
| 21. Round | 28/02/2022 | Wolverhampton Wanderers U23 | - | Reading FC U23 | 4:3 | ||||
| 15. Round | 06/03/2022 | Birmingham City U23 | - | Reading FC U23 | 0:0 | |
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| 23. Round | 20/03/2022 | Southampton FC U23 | - | Reading FC U23 | 2:1 | ||||
| 24. Round | 01/04/2022 | Reading FC U23 | - | West Bromwich Albion U23 | 1:1 | ||||
| 25. Round | 25/04/2022 | Reading FC U23 | - | Fulham FC U23 | 3:1 |
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