| 7. Round | 11/09/2021 | Plymouth Argyle | - | Sheffield Wednesday | 3:0 | ||||
| 8. Round | 18/09/2021 | AFC Wimbledon | - | Plymouth Argyle | 0:1 | ||||
| 6. Round | 21/09/2021 | Portsmouth FC | - | Plymouth Argyle | 2:2 | ||||
| 9. Round | 25/09/2021 | Plymouth Argyle | - | Doncaster Rovers | 2:1 | ||||
| 10. Round | 28/09/2021 | Plymouth Argyle | - | Crewe Alexandra | 1:1 | ||||
| 11. Round | 02/10/2021 | Lincoln City | - | Plymouth Argyle | 2:2 | ||||
| 12. Round | 09/10/2021 | Plymouth Argyle | - | Burton Albion | 2:1 | ||||
| 15. Round | 23/10/2021 | Morecambe FC | - | Plymouth Argyle | 1:1 | ||||
| 17. Round | 13/11/2021 | Accrington Stanley | - | Plymouth Argyle | 1:4 | ||||
| 20. Round | 27/11/2021 | Plymouth Argyle | - | Wigan Athletic | 1:2 | ||||
| 23. Round | 18/12/2021 | Plymouth Argyle | - | Charlton Athletic | 1:0 |  |
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| 24. Round | 26/12/2021 | Cheltenham Town | - | Plymouth Argyle | 0:2 |
England
St. Vincent/Grenadines