| 1. Round | 16/08/2021 | Stoke City U23 | - | Birmingham City U23 | 2:1 | ||||
| 4. Round | 13/09/2021 | Middlesbrough FC U23 | - | Stoke City U23 | 2:0 | ||||
| 5. Round | 20/09/2021 | Newcastle United U23 | - | Stoke City U23 | 2:3 |  |
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| 6. Round | 27/09/2021 | Stoke City U23 | - | Aston Villa U23 | 0:8 | ||||
| 7. Round | 01/10/2021 | Southampton FC U23 | - | Stoke City U23 | 1:1 | ||||
| 8. Round | 18/10/2021 | Stoke City U23 | - | Nottingham Forest U23 | 1:0 | ||||
| 9. Round | 25/10/2021 | West Bromwich Albion U23 | - | Stoke City U23 | 1:1 | ||||
| 10. Round | 01/11/2021 | Stoke City U23 | - | Wolverhampton Wanderers U23 | 2:0 |  |
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| 11. Round | 07/11/2021 | Stoke City U23 | - | Sunderland AFC U23 | 2:2 | |
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| 12. Round | 19/11/2021 | Fulham FC U23 | - | Stoke City U23 | 3:0 | ||||
| 13. Round | 26/11/2021 | Burnley FC U23 | - | Stoke City U23 | 0:1 | ||||
| 14. Round | 06/12/2021 | Stoke City U23 | - | Southampton FC U23 | 3:0 | ||||
| 17. Round | 14/01/2022 | Birmingham City U23 | - | Stoke City U23 | 1:1 | |
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| 18. Round | 24/01/2022 | Stoke City U23 | - | Fulham FC U23 | 0:1 | ||||
| 19. Round | 07/02/2022 | Reading FC U23 | - | Stoke City U23 | 1:1 |
England