| 3. Round | 17/08/2021 | Morecambe FC | - | Rotherham United | 0:1 | ||||
| 4. Round | 21/08/2021 | Rotherham United | - | Sheffield Wednesday | 0:2 | ||||
| 5. Round | 28/08/2021 | Rotherham United | - | Doncaster Rovers | 2:0 | ||||
| 7. Round | 11/09/2021 | Rotherham United | - | Fleetwood Town | 2:4 |  |
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| 6. Round | 14/09/2021 | Lincoln City | - | Rotherham United | 1:1 | ||||
| 8. Round | 18/09/2021 | Bolton Wanderers | - | Rotherham United | 0:2 | ||||
| 11. Round | 02/10/2021 | Cheltenham Town | - | Rotherham United | 0:2 | ||||
| 16. Round | 30/10/2021 | Rotherham United | - | Sunderland AFC | 5:1 | ||||
| 18. Round | 20/11/2021 | Rotherham United | - | Cambridge United | 3:1 | ||||
| 19. Round | 23/11/2021 | Ipswich Town | - | Rotherham United | 0:2 | ||||
| 22. Round | 11/12/2021 | Rotherham United | - | Burton Albion | 3:1 | ||||
| 26. Round | 01/01/2022 | Rotherham United | - | Bolton Wanderers | 2:1 |
England