| 1. Round | 04/09/2021 | Tottenham Hotspur WFC [Women] | - | Birmingham City WFC [Women] | 1:0 |  |
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| 2. Round | 12/09/2021 | Manchester City WFC [Women] | - | Tottenham Hotspur WFC [Women] | 1:2 | ||||
| 3. Round | 26/09/2021 | Tottenham Hotspur WFC [Women] | - | Reading WFC [Women] | 1:0 | ||||
| 4. Round | 03/10/2021 | Leicester City WFC [Women] | - | Tottenham Hotspur WFC [Women] | 0:2 | ||||
| 5. Round | 10/10/2021 | Brighton & Hove Albion WFC [Women] | - | Tottenham Hotspur WFC [Women] | 2:1 | |
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| 6. Round | 07/11/2021 | Tottenham Hotspur WFC [Women] | - | Manchester United WFC [Women] | 1:1 | ||||
| 7. Round | 13/11/2021 | Tottenham Hotspur WFC [Women] | - | Arsenal WFC [Women] | 1:1 | ||||
| 8. Round | 21/11/2021 | West Ham United WFC [Women] | - | Tottenham Hotspur WFC [Women] | 1:0 |  |
England