| 31. Round | 08/02/2022 | Carlisle United | - | Port Vale FC | 1:3 | ||||
| 32. Round | 12/02/2022 | Colchester United | - | Carlisle United | 2:2 | ||||
| 33. Round | 19/02/2022 | Carlisle United | - | Swindon Town | 0:3 | ||||
| 34. Round | 26/02/2022 | Leyton Orient | - | Carlisle United | 0:1 | ||||
| 23. Round | 01/03/2022 | Carlisle United | - | Rochdale AFC | 2:0 | ||||
| 35. Round | 05/03/2022 | Oldham Athletic | - | Carlisle United | 1:2 | ||||
| 36. Round | 12/03/2022 | Carlisle United | - | Northampton Town | 2:1 | ||||
| 37. Round | 15/03/2022 | Carlisle United | - | Newport County | 1:2 | ||||
| 38. Round | 19/03/2022 | Barrow AFC | - | Carlisle United | 1:2 |  |
 |
||
| 39. Round | 26/03/2022 | Carlisle United | - | Bristol Rovers | 1:0 | |
|
||
| 30. Round | 29/03/2022 | Rochdale AFC | - | Carlisle United | 2:0 | ||||
| 40. Round | 02/04/2022 | Tranmere Rovers | - | Carlisle United | 2:2 | ||||
| 41. Round | 09/04/2022 | Carlisle United | - | Exeter City | 0:1 | ||||
| 42. Round | 15/04/2022 | Walsall FC | - | Carlisle United | 1:0 | ||||
| 44. Round | 23/04/2022 | Harrogate Town | - | Carlisle United | 3:0 | ||||
| 45. Round | 30/04/2022 | Carlisle United | - | Stevenage FC | 2:1 | ||||
| 46. Round | 07/05/2022 | Bradford City | - | Carlisle United | 2:0 |
England